Abstract
The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) [1] was isolated as the anti-HIV principle of Excoecaria agallocha leaves and stems collected in northwest Australia. The structure was determined by spectral means. Compound 1 was also a potent displacer of [3H]-phorbol dibutyrate from rat brain membranes.
MeSH terms
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Animals
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Chromatography, Liquid
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HIV-1 / drug effects
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HIV-1 / physiology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry / methods
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Phorbol Esters / chemistry
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Phorbol Esters / isolation & purification*
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Phorbol Esters / pharmacology
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Plants, Medicinal / chemistry*
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Rats
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Virus Replication / drug effects
Substances
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12-deoxyphorbol 13-(3,5-decadienoate)
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Antiviral Agents
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Phorbol Esters